Introduction：Basic information about CAS 127633-71-0|(β-Ala8)-Neurokinin A (4-10), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].
Related Catalog
Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
In Vivo
(β-Ala8)-Neurokinin A (4-10) (2 μg/kg; i.v.) increases colonic tone in conscious female dogs[2].
References
[1]. C A Maggi, et al. In vivo pharmacology of [beta Ala8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur J Pharmacol. 1990 Feb 20;177(1-2):81-6.
[2]. G Basilisco, et al. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Aliment Pharmacol Ther. 1994 Oct;8(5):527-33.
Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats.
Peptides 11 , 293-297, (1990)
We have developed a novel series of peptides, related to the NKA(4-10) sequence, in which substitution of selected amino acids determined variations in the affinity for the TK receptor subtypes. Subcu...
Tachykinin-induced responses via neurokinin-1 and -3 receptors in hamster submandibular ganglion neurones.
Arch. Oral Biol. 44 , 455-463, (1999)
Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ga...
