Introduction：Basic information about CAS 54784-44-0|a d lh-rh, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | a d lh-rh |
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| CAS Number | 54784-44-0 | Molecular Weight | 1206.35000 |
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| Density | 1.46g/cm3 | Boiling Point | / |
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| Molecular Formula | C59H79N15O13 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | a d lh-rh |
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| Synonym | More Synonyms |
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a d lh-rh BiologicalActivity
| Description | [D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1]. |
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| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Others |
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| In Vivo | [D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1]. [D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2].[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3]. [D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4]. Animal Model: Adult female Sprague-Dawley rats (200-250 g)[2] Dosage: 1 mg/rat Administration: SC injections, from 12:00 to 14:30 hr on the day of proestrus Result: Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation. |
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| References | [1]. Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. [2]. Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. [3]. Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. [4]. Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23. |
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Chemical & Physical Properties
| Density | 1.46g/cm3 |
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| Molecular Formula | C59H79N15O13 |
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| Molecular Weight | 1206.35000 |
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| Exact Mass | 1205.60000 |
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| PSA | 443.45000 |
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| LogP | 2.77280 |
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| Index of Refraction | 1.687 |
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| InChIKey | VQKMKQJDJGQSDZ-SZYFUYGVSA-N |
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| SMILES | CC(C)CC(NC(=O)C(C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OK6600000
- CHEMICAL NAME :
- Luteinizing hormone-releasing hormone, (D-phe(sup 2))-(D-ala(sup 6))-
- CAS REGISTRY NUMBER :
- 54784-44-0
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C59-H79-N15-O13
- MOLECULAR WEIGHT :
- 1206.53
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3750 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1247,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 12500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975
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Safety Information
| Risk Phrases | 60 |
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| Safety Phrases | 53-22-36/37/39-45 |
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Synonyms
| GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2 |
| [D-PHE2,D-ALA6]-LH-RH (HUMAN) |
| PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 |
| [D-PHE2,D-ALA6]-LH-RH |
| PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 |
| D-phe2,D-ala6-luteinizing hormone*releasing hormo |
| wy-18,185 |
| LHRH,Phe(2)-Ala(6) |
| (d-phe(sup2))-(d-ala(sup6))-lhrh |
