Introduction：Basic information about CAS 149231-66-3|Ac-YVAD-pNA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-YVAD-pNA |
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| CAS Number | 149231-66-3 | Molecular Weight | 628.63 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 1108.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C29H36N6O10 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 624.5±34.3 °C |
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Names
| Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid |
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| Synonym | More Synonyms |
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Ac-YVAD-pNA BiologicalActivity
| Description | Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
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| Target | Caspase-1 |
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| References | [1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7. [2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 1108.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C29H36N6O10 |
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| Molecular Weight | 628.63 |
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| Flash Point | 624.5±34.3 °C |
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| Exact Mass | 628.249268 |
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| PSA | 248.85000 |
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| LogP | 2.61 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.605 |
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| InChIKey | YDPNOCSPPGFBPX-XNHCRPTKSA-N |
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| SMILES | CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)Nc1ccc([N+](=O)[O-])cc1)C(C)C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Ac-Tyr-Val-Ala-Asp-PNA |
| IL-1beta Converting Enzyme (ICE) Colorimetric Substrate |
| Ac-Tyr-Val-Ala-Asp-paranitroanilide |
| L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)- |
| N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine |
| Caspase-1 Substrate IV,Colorimetric |
| Ac-YVAD-pNA |
