Introduction：Basic information about CAS 20123-80-2|Calcium dobesilate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Calcium dobesilate |
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| CAS Number | 20123-80-2 | Molecular Weight | 418.410 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C12H10CaO10S2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | calcium,2,5-dihydroxybenzenesulfonate |
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| Synonym | More Synonyms |
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Calcium dobesilate BiologicalActivity
| Description | Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Allain H, et al. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Saf. 2004;27(9):649-60. |
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Chemical & Physical Properties
| Molecular Formula | C12H10CaO10S2 |
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| Molecular Weight | 418.410 |
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| Exact Mass | 417.934143 |
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| PSA | 212.08000 |
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| LogP | 2.16540 |
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| InChIKey | QGNBTYAQAPLTMX-UHFFFAOYSA-L |
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| SMILES | O=S(=O)([O-])c1cc(O)ccc1O.O=S(=O)([O-])c1cc(O)ccc1O.[Ca+2] |
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| Storage condition | room temp |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DB6127000
- CHEMICAL NAME :
- Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt
- CAS REGISTRY NUMBER :
- 20123-80-2
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C12-H10-O10-S2.Ca
- MOLECULAR WEIGHT :
- 418.42
- WISWESSER LINE NOTATION :
- WSO&R BQ EQ 2 &-CA-
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7061 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7549 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 876 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 775 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 30,415,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3509207
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4979 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2908999090 |
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| Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1) |
| calcium 2,5-dihydroxybenzenesulfonate |
| Calcium dobesilate |
| Nugatex |
| Dobesilat-Calciumsalz |
| Dobesilato calcico |
| Calcium Doxybensylate |
| calcium salt of 2,5-dihydroxybenzenesulfonic acid |
| Doxium |
| Calcii dobesilas |
| MFCD08457542 |
| calcium 2,5-dihydroxy-phenylsulfonate |
| 2,5-Dihydroxybenzenesulfonic acid calcium salt,205E,Calcium 2,5-dihydroxybenzenesulfonate |
| Dobesilate calcium |
| 2,5-dihydroxybenzenesulfonic acid calcium salt |
| Calcium bis(2,5-dihydroxybenzenesulfonate) |
| Rasexinium |
| EINECS 243-531-5 |
| Dexium |
| Toraxine |
