CAS 15301-69-6|BML-278

Introduction：Basic information about CAS 15301-69-6|BML-278, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BML-278 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	BML-278
CAS Number	15301-69-6	Molecular Weight	391.460
Density	1.2±0.1 g/cm3	Boiling Point	564.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₅NO₄	Melting Point	/
MSDS	/	Flash Point	294.9±30.1 °C

Names

Name	flavoxate
Synonym	More Synonyms

BML-278 BiologicalActivity

Description	Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Signaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease
References	[1]. Arcaniolo D, et al. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31. [2]. Sugaya K, et al. Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol. 2014 Oct;192(4):1278-85.

Description

Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Signaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease

References

[1]. Arcaniolo D, et al. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31.

[2]. Sugaya K, et al. Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol. 2014 Oct;192(4):1278-85.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	564.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₅NO₄
Molecular Weight	391.460
Flash Point	294.9±30.1 °C
Exact Mass	391.178345
PSA	59.75000
LogP	5.18
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.591
InChIKey	SPIUTQOUKAMGCX-UHFFFAOYSA-N
SMILES	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O

Synonyms

flavoxate

3-Methylflavone-8-carboxylic Acid b-Piperidinoethyl Ester

Genurin

Flavossato [DCIT]

Flavoxatum [INN-Latin]

3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic Acid 2-(1-Piperidinyl)ethyl Ester

Flavoxato [INN-Spanish]

MFCD00210291

Flavossato

Flavoxate [INN:BAN]

Flavoxatum

REC 7-0040

2-(Piperidin-1-yl)ethyl-3-methyl-4-oxo-2-phenyl-4H-chromen-8-carboxylat

2-(Piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate

2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

Urispas

2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate

2-Piperidinoethyl 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate

EINECS 239-337-5

Bladderon

Spasuret

2-Piperidinoethyl 3-Methylflavone-8-carboxylate

Flavoxato

4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester

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