CAS 73231-34-2|Florfenicol

Introduction：Basic information about CAS 73231-34-2|Florfenicol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Florfenicol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles22
8. Synonyms

Common Name	Florfenicol
CAS Number	73231-34-2	Molecular Weight	358.213
Density	1.5±0.1 g/cm3	Boiling Point	617.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₄Cl₂FNO₄S	Melting Point	153 °C
MSDS	ChineseUSA	Flash Point	327.3±31.5 °C

Names

Name	florfenicol
Synonym	More Synonyms

Florfenicol BiologicalActivity

Description	Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213. [2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology Volume 57, Issue 4, pages 1064–1073, August 2005

Description

Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213.

[2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology Volume 57, Issue 4, pages 1064–1073, August 2005

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	617.5±55.0 °C at 760 mmHg
Melting Point	153 °C
Molecular Formula	C₁₂H₁₄Cl₂FNO₄S
Molecular Weight	358.213
Flash Point	327.3±31.5 °C
Exact Mass	357.000458
PSA	91.85000
LogP	-0.12
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.548
InChIKey	AYIRNRDRBQJXIF-NXEZZACHSA-N
SMILES	CS(=O)(=O)c1ccc(C(O)C(CF)NC(=O)C(Cl)Cl)cc1
Storage condition	0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB6034000

CHEMICAL NAME :: Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))-

CAS REGISTRY NUMBER :: 73231-34-2

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H11-Cl2-F-N2-O4

MOLECULAR WEIGHT :: 325.14

WISWESSER LINE NOTATION :: WNR DYQY1FMVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles22

Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.

Food Chem. 178 , 63-9, (2015)

A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammator...

Development and validation of determinative and confirmatory LC-MS/MS methodologies for total florfenicol and tulathromycin residues in bovine, equine and porcine kidney, liver and muscle tissues.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 1-9, (2015)

Separate methods for the quantitation and confirmation of regulatory relevant residue concentrations of total florfenicol and tulathromycin residues in multiple tissue matrices were developed and vali...

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography.

Anal. Chim. Acta 871 , 57-65, (2015)

In this study, methacrylic acid (MAA) was incorporated with alkyl methacrylates to increase the hydrophilicity of the synthesized ethylene dimethacrylate-based (EDMA-based) monoliths for separating po...

Synonyms

Florfenicol

2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide

NUFLOR

2,2-dichloro-N-[(1S

AQUAFEN

Fluorothiamphenicol

2,2-DIBROMODECAFLUOROPENTANE

2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

Florfeniol

Aquaflor

MFCD00864834

EINECS 642-986-0

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