CAS 67920-52-9|Sodium Danshensu

Introduction：Basic information about CAS 67920-52-9|Sodium Danshensu, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sodium Danshensu BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Sodium Danshensu
CAS Number	67920-52-9	Molecular Weight	220.154
Density	/	Boiling Point	/
Molecular Formula	C₉H₉NaO₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Sodium danshensu
Synonym	More Synonyms

Sodium Danshensu BiologicalActivity

Description	Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2]
Related Catalog	Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>OthersNatural Products >>Phenylpropanoids
References	[1]. Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8. [2]. Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86.

Description

Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2]

Related Catalog

Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>OthersNatural Products >>Phenylpropanoids

References

[1]. Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8.

[2]. Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86.

Chemical & Physical Properties

Molecular Formula	C₉H₉NaO₅
Molecular Weight	220.154
Exact Mass	220.034775
PSA	100.82000
Storage condition	2-8°C

Safety Information

Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	24/25

Synonyms

Sodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate

3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt

Benzenepropanoic acid, α,3,4-trihydroxy-, sodium salt (1:1)

Danshensu (sodium salt)

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