CAS 35380-71-3|ESTRADIOL HEMIHYDRATE
Introduction：Basic information about CAS 35380-71-3|ESTRADIOL HEMIHYDRATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ESTRADIOL HEMIHYDRATE | ||
|---|---|---|---|
| CAS Number | 35380-71-3 | Molecular Weight | 562.779 |
| Density | / | Boiling Point | 445.9ºC at 760mmHg |
| Molecular Formula | C18H26O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 209.6ºC |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate |
|---|---|
| Synonym | More Synonyms |
ESTRADIOL HEMIHYDRATE BiologicalActivity
| Description | Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>CancerResearch Areas >>Neurological Disease |
| In Vitro | Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1]. Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1]. Cell Differentiation Assay[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively. Immunofluorescence[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively. |
| In Vivo | Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1]. Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1]. Animal Model: FBN-ARO-KO Mice[2] Dosage: 1 nM Administration: Treated for the hippocampal slices Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice. Animal Model: FBN-ARO-KO Mice[2] Dosage: 0.0167 mg Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation. Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects. |
| References | [1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153. [2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809. |
Chemical & Physical Properties
| Boiling Point | 445.9ºC at 760mmHg |
|---|---|
| Molecular Formula | C18H26O3 |
| Molecular Weight | 562.779 |
| Flash Point | 209.6ºC |
| Exact Mass | 562.365845 |
| PSA | 49.69000 |
| LogP | 3.54490 |
| InChIKey | ZVVGLAMWAQMPDR-WVEWYJOQSA-N |
| SMILES | CC12CCC3c4ccc(O)cc4CCC3C1CCC2O.CC12CCC3c4ccc(O)cc4CCC3C1CCC2O.O |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H351-H360Fd-H362 |
| Precautionary Statements | P201-P263-P281-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | 60-63-40-64 |
| Safety Phrases | 53-36/37-45 |
| RIDADR | NONH for all modes of transport |
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Synonyms
| (17β)-Estra-1,3,5(10)-triene-3,17-diol hydrate (2:1) |
| ESTRADIOL HEMIHYDRATE |
| cxy7b3q98z |
| Estra-1,3,5(10)-triene-3,17-diol, (17β)-, hydrate (2:1) |
| Estra-1,3,5(10)-triene-3,17β-diol hydrate (2:1) |
| unii-cxy7b3q98z |
