CAS 51-41-2|Norepinephrine
Introduction：Basic information about CAS 51-41-2|Norepinephrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Norepinephrine | ||
|---|---|---|---|
| CAS Number | 51-41-2 | Molecular Weight | 169.178 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 442.6±40.0 °C at 760 mmHg |
| Molecular Formula | C8H11NO3 | Melting Point | 220-230°C |
| MSDS | ChineseUSA | Flash Point | 221.5±27.3 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | (R)-noradrenaline |
|---|---|
| Synonym | More Synonyms |
Norepinephrine BiologicalActivity
| Description | Norepinephrine is a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Myburgh J, et al. Norepinephrine: more of a neurohormone than a vasopressor. Crit Care. 2010;14(5):196. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 442.6±40.0 °C at 760 mmHg |
| Melting Point | 220-230°C |
| Molecular Formula | C8H11NO3 |
| Molecular Weight | 169.178 |
| Flash Point | 221.5±27.3 °C |
| Exact Mass | 169.073898 |
| PSA | 86.71000 |
| LogP | -0.88 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.659 |
| InChIKey | SFLSHLFXELFNJZ-QMMMGPOBSA-N |
| SMILES | NCC(O)c1ccc(O)c(O)c1 |
| Storage condition | 2-8°C |
| Stability | Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20C. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 8 mg/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 60 ug/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 7-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 10 ug/kg
- SEX/DURATION :
- female 63 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Vascular - measurement of regional blood flow Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 7-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - hepatobiliary system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 7-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 5800 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1414,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1103 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 85 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1103 No. of Facilities: 68 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 613 (estimated) No. of Female Employees: 175 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 5800 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1414,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1103 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 85 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1103 No. of Facilities: 68 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 613 (estimated) No. of Female Employees: 175 (estimated)
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330 |
| Precautionary Statements | P260-P264-P280-P284-P302 + P350-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+:Verytoxic; |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S28-S36/37-S45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DN5950000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (−)-Norepinephrine |
| (-)-NORADRENALINE |
| 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- |
| 4-[(1R)-2-amino-1-hydroxyéthyl]benzène-1,2-diol |
| L-NOREPINEPHRINE |
| 4-((R)-2-Amino-1-hydroxy-ethyl)-benzene-1,2-diol |
| 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- |
| EINECS 205-750-4 |
| (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol |
| norepinephrinum [INN_la] |
| noradrenaline |
| 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- |
| L-NORADRENALINE |
| (R)-(-)-norepinephrine |
| (-)-a-(Aminomethyl)protocatechuyl alcohol |
| 4-[(1R)-2-Amino-1-hydroxyethyl]benzol-1,2-diol |
| Noradrenalin |
| (-)-norepinephrine |
| (R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol |
| (R)-norepinephrine |
| MFCD00025592 |
| (R)-noradrenaline |
| 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol |
| Norepinephrine |
| (-)-(R)-Norepinephrine |
| 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- |
| 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol |
