CAS 5746-86-1|(±)-Nornicotine

Introduction：Basic information about CAS 5746-86-1|(±)-Nornicotine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (±)-Nornicotine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles30
8. Synonyms

Common Name	(±)-Nornicotine
CAS Number	5746-86-1	Molecular Weight	148.20500
Density	1,074 g/cm3	Boiling Point	107-108°C 2mm
Molecular Formula	C₉H₁₂N₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	101°C
Symbol	GHS07	Signal Word	Warning

Names

Name	3-(2-Pyrrolidinyl)pyridine
Synonym	More Synonyms

(±)-Nornicotine BiologicalActivity

Description
Target	Human Endogenous Metabolite

Chemical & Physical Properties

Density	1,074 g/cm3
Boiling Point	107-108°C 2mm
Molecular Formula	C₉H₁₂N₂
Molecular Weight	148.20500
Flash Point	101°C
Exact Mass	148.10000
PSA	24.92000
LogP	1.83490
Index of Refraction	1.54
InChIKey	MYKUKUCHPMASKF-UHFFFAOYSA-N
SMILES	c1cncc(C2CCCN2)c1
Storage condition	2-8°C
Water Solubility	H2O: 50 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS6350000

CHEMICAL NAME :: Nicotine, 1'-demethyl-, (+-)-

CAS REGISTRY NUMBER :: 5746-86-1

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H12-N2

MOLECULAR WEIGHT :: 148.23

WISWESSER LINE NOTATION :: T6NJ C- BT5MTJ -+-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18750 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S36/37
RIDADR	2810
WGK Germany	3
RTECS	QS6350000
Packaging Group	III
Hazard Class	6.1
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles30

6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.

Bioorg. Med. Chem. Lett. 15 , 877-81, (2005)

6'-Methylpyrido[3,4-b]norhomotropane [synthesis as the racemate reported here] is more potent at the alpha4beta2 nicotinic receptor than any previous bridged nicotinoid. The two nitrogens and 6'-methy...

3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

Bioorg. Med. Chem. Lett. 15 , 4308-12, (2005)

An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted...

Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.

Nicotine Tob. Res. 15(3) , 622-32, (2013)

This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their...

Synonyms

3-pyrrolidin-2-yl-pyridine

EINECS 200-659-6

NORNICOTINE,DL

2-[3-PYRIDYL]PYRROLIDINE

(+/-)-nor-nicotine

(2S)-2-(3-Pyridinyl)pyrrolidinium

2-(3-pyridyl)pyrollidine

MFCD00016913

2-[3-PYRIDYL]PYRROLIDONE

DL-NORNICOTINE

2-(3-Pyridinyl)pyrrolidine

(R,S)-NORNICOTINE

Pyrrolidinium, 2-(3-pyridinyl)-, (2S)-

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