Introduction：Basic information about CAS 863-57-0|sodium glycocholate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | sodium glycocholate |
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| CAS Number | 863-57-0 | Molecular Weight | 487.604 |
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| Density | / | Boiling Point | 692ºC at 760 mmHg |
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| Molecular Formula | C26H42NNaO6 | Melting Point | 210-215 °C (subl.)(lit.) |
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| MSDS | / | Flash Point | 372.3ºC |
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Names
| Name | sodium glycocholate |
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| Synonym | More Synonyms |
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sodium glycocholate BiologicalActivity
| Description | Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. |
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| Related Catalog | Research Areas >>Others |
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| Target | Microbial Metabolite Human Endogenous Metabolite |
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| In Vitro | Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. |
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Chemical & Physical Properties
| Boiling Point | 692ºC at 760 mmHg |
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| Melting Point | 210-215 °C (subl.)(lit.) |
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| Molecular Formula | C26H42NNaO6 |
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| Molecular Weight | 487.604 |
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| Flash Point | 372.3ºC |
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| Exact Mass | 487.290985 |
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| PSA | 129.92000 |
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| LogP | 1.62110 |
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| Index of Refraction | 30 ° (C=1, H2O) |
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| InChIKey | OABYVIYXWMZFFJ-UHFFFAOYSA-M |
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| SMILES | CC(CCC(=O)NCC(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.[Na+] |
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| Storage condition | Refrigerator |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MB9265100
- CHEMICAL NAME :
- Glycine, N-choloyl-, monosodium salt
- CAS REGISTRY NUMBER :
- 863-57-0
- LAST UPDATED :
- 199404
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C26-H43-N-O6.Na
- MOLECULAR WEIGHT :
- 488.69
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80519 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
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Safety Information
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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| RTECS | MB9265100 |
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Synonyms
| Glycine, N-choloyl-, monosodium salt |
| EINECS 212-730-9 |
| sodium {[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate |
| GLYCOCHOLIC ACID SODIUM SALT |
| Glycine, N-((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)-, monosodium salt (9CI) |
| MFCD00036741 |
| Sodium {[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate |
| Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1) |
| Sodium glycocholate hydrate |
| glycine, N-[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1) |
