CAS 551-08-6|3-Butylidenephthalide
| Common Name | 3-Butylidenephthalide | ||
|---|---|---|---|
| CAS Number | 551-08-6 | Molecular Weight | 188.223 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 312.0±35.0 °C at 760 mmHg |
| Molecular Formula | C12H12O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 127.9±23.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (Z)-3-butylidenephthalide |
|---|---|
| Synonym | More Synonyms |
3-Butylidenephthalide BiologicalActivity
| Description | 3-Butylidenephthalide (Butylidenephthalide) is a phthalic anhydride derivative identified in Ligusticum chuanxiong Hort, and has larvicidal activity (LC50 of 1.56 mg/g for Spodoptera litura larvae)[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Yi Y, et al. Z-Ligustilide Exerted Hormetic Effect on Growth and Detoxification Enzymes of Spodoptera lituraLarvae. Evid Based Complement Alternat Med. 2018 Jul 2;2018:7104513. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 312.0±35.0 °C at 760 mmHg |
| Molecular Formula | C12H12O2 |
| Molecular Weight | 188.223 |
| Flash Point | 127.9±23.4 °C |
| Exact Mass | 188.083725 |
| PSA | 26.30000 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.631 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,659,1983 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,659,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,659,1983
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S23 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | TI3692500 |
Articles28
More Articles| Identification of Aroma-active Compounds in Essential Oil from Uncaria Hook by Gas Chromatography- Mass Spectrometry and Gas Chromatography-Olfactometry. J. Oleo Sci. 64 , 825-33, (2015) The chemical composition of essential oil extracted from Uncaria Hook ("Chotoko" in Japanese), the branch with curved hook of the herbal medicine Uncaria rhynchophylla has been investigated by GC and ... | |
| Cinidium officinale and its Bioactive Compound, Butylidenephthalide, Inhibit Laser-Induced Choroidal Neovascularization in a Rat Model. Molecules 20 , 20699-708, (2015) Choroidal neovascularization (CNV) is a common pathology in age-related macular degeneration. In this study, we evaluated in a rat model the effect of an extract of Cinidium officinale Makino and its ... | |
| (Z)-3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor. J. Nat. Prod. 74 , 314-20, (2011) An extract from the roots of Ligusticum porteri, orally administered to groups of normal and diabetic mice, showed significant hypoglycemic and antihyperglycemic effects. Experimental type-II DM was a... |
Synonyms
| 1(3H)-Isobenzofuranone, 3-butylidene-, (3Z)- |
| MFCD00047319 |
| 1(3H)-Isobenzofuranone, 3-butylidene- |
| 3-butylidene-3H-isobenzofuran-1-one |
| Bdph |
| N-BUTYLIDENEPHTHALIDE |
| ligusticumlactone |
| 3-Butylidenephtalide |
| 3-butylidene-phthalid |
| (3Z)-3-Butylidene-2-benzofuran-1(3H)-one |
| 3-Butylidene Phthalide |
| BUTYLIDENE PHTHALIDE |
| EINECS 208-991-3 |
