Introduction：Basic information about CAS 142-88-1|Piperazine adipate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
Related Catalog
Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection
In Vitro
Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[1].
References
[1]. Sharma RK, et al. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20.
Chemical & Physical Properties
Boiling Point
338.5ºC at 760 mmHg
Melting Point
250ºC (Decomposes)
Molecular Formula
C10H20N2O4
Molecular Weight
232.27700
Flash Point
172.7ºC
Exact Mass
232.14200
PSA
98.66000
LogP
0.55280
Vapour Pressure
1.81E-05mmHg at 25°C
InChIKey
BVEGEKOBSPXUJS-UHFFFAOYSA-N
SMILES
C1CNCCN1.O=C(O)CCCCC(=O)O
Stability
Stable. Combustible. Incompatible with strong oxidizing agents. May be light-sensitive.
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
MO1955000
CAS REGISTRY NUMBER :
142-88-1
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H10-O4.C4-H10-N2
MOLECULAR WEIGHT :
232.32
WISWESSER LINE NOTATION :
T6N DNTJ &QV4VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982
Safety Information
RIDADR
NONH for all modes of transport
RTECS
MO1955000
HS Code
2933599090
Customs
HS Code
2933599090
Summary
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles9
More Articles
The effect of piperazine adipate and parbendazole on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae.
Angew. Parasitol. 28(4) , 207-10, (1987)
Carbohydrate metabolism of Ascardia galli and Heterakis gallinae was studied after their exposure in vitro to 10(-2) to 10(-5) M piperazine adipate and parbendazole for 10 to 60 min. Following treatme...
[Study of compounds with potential antiparasitic effect. V. Antihistaminics].
Wiad. Parazytol. 26(1) , 59-64, (1980)
[Experience with the prevention of enterobiasis in children from preschool institutions of the Zhitomir district].
