CAS 110044-82-1|Calpain Inhibitor I
| Common Name | Calpain Inhibitor I | ||
|---|---|---|---|
| CAS Number | 110044-82-1 | Molecular Weight | 383.526 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 632.2±50.0 °C at 760 mmHg |
| Molecular Formula | C20H37N3O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 192.9±30.3 °C |
Names
| Name | acetylleucyl-leucyl-norleucinal |
|---|---|
| Synonym | More Synonyms |
Calpain Inhibitor I BiologicalActivity
| Description | MG-101 is a potent inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Cancer |
| References | [1]. Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437(2):325-330. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 632.2±50.0 °C at 760 mmHg |
| Molecular Formula | C20H37N3O4 |
| Molecular Weight | 383.526 |
| Flash Point | 192.9±30.3 °C |
| Exact Mass | 383.278412 |
| PSA | 104.37000 |
| LogP | 3.37 |
| Appearance of Characters | powder | white |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.474 |
| InChIKey | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
| SMILES | CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O |
| Storage condition | −20°C |
| Water Solubility | DMSO: soluble | Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles64
More Articles| Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS ONE 10(3) , e0119423, (2015) Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In... | |
| The role of proteases in excitation-contraction coupling failure in muscular dystrophy. Am. J. Physiol. Cell Physiol. 308(1) , C33-40, (2015) Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in D... | |
| Necrosis- and apoptosis-related Met cleavages have divergent functional consequences. Cell Death Dis. 6 , e1769, (2015) Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregu... |
Synonyms
| N-Acetyl-L-leucyl-N-[(2S)-1-oxohexan-2-yl]-L-leucinamide |
| ALLN Ac-LLnL-CHO MG-101 N-Acetyl-Leu-Leu-Norleu-al N-Acetyl-L-leucyl-L-leucyl-L-norleucinal |
| Ac-Leu-Leu-Nle-H |
| AC-LL-NORLEUCINAL |
| AC-LEU-LEU-NORLEUCINAL |
| Ac-Leu-Leu-Nle-al |
| Calpain Inhibitor I,ALLN |
| CALPAIN INHIBITOR I |
| MG 101 |
| ALLN |
| N-Acetyl-L-leucyl-N-((1S)-1-formylpentyl)-L-leucinamide |
| ac-llnl-cho |
| AC-LEU-LEU-NLE-CHO |
| acetylleucyl-leucyl-norleucinal |
| N-Acetyl-L-leucyl-N-[(2S)-1-oxo-2-hexanyl]-L-leucinamide |
| L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- |
| LLNL |
| CALPAIN INHIBITOR |
| MFCD00065505 |
