Introduction：Basic information about CAS 110115-07-6|ALLM, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ALLM |
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| CAS Number | 110115-07-6 | Molecular Weight | 401.564 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 676.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H35N3O4S | Melting Point | / |
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| MSDS | Chinese | Flash Point | 362.9±31.5 °C |
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Names
| Name | calpain inhibitor ii |
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| Synonym | More Synonyms |
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ALLM BiologicalActivity
| Description | ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Neurological DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Cathepsin |
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| In Vivo | ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2]. ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2]. Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2] Dosage: 0.05, 0.5, and 2.5 mg/kg Administration: Intraperitoneally; every 24 h for 1 week Result: Showed significantly better motor function. |
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| References | [1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9. [2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 676.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H35N3O4S |
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| Molecular Weight | 401.564 |
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| Flash Point | 362.9±31.5 °C |
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| Exact Mass | 401.234833 |
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| PSA | 129.67000 |
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| LogP | 2.64 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.496 |
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| InChIKey | RJWLAIMXRBDUMH-ULQDDVLXSA-N |
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| SMILES | CSCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O |
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| Storage condition | −20°C |
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| Water Solubility | Very slightly soluble (0.52 g/L) (25 ºC) |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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Synonyms
| N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide |
| N-AC-LEU-LEU-METHIONINAL |
| AC-LEU-LEU-L-METHIONINAL |
| L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]- |
| Ac-Leu-Leu-Met-al |
| N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide |
| ALLM |
| AC-LEU-LEU-MET-ALDEHYDE |
| AC-LEU-LEU-METHIONINAL |
| AC-LEU-LEU-MET-CHO |
| N-ACETYL-LEU-LEU-MET-CHO |
| MFCD00065506 |
| AC-LLM-CHO |
