Introduction：Basic information about CAS 90697-57-7|Motapizone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Motapizone |
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| CAS Number | 90697-57-7 | Molecular Weight | 260.31 |
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| Density | 1.47g/cm3 | Boiling Point | / |
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| Molecular Formula | C12H12N4OS | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one |
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| Synonym | More Synonyms |
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Motapizone BiologicalActivity
| Description | Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology |
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| Target | PDE3 |
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| In Vitro | Motapizone (10 μM; 加氧化剂前 15 min) 在氧化应激条件下，对脂多糖 (LPS) 诱导的肺泡巨噬细胞的细胞因子释放有 20% 的抑制率，不过，这种抑制作用不受氧化应激影响[1]。 |
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| References | [1]. Milara J, et al. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin Exp Allergy. 2011 Apr;41(4):535-46. [2]. Borbe HO, et al. Inhibition of human platelet aggregation by motapizone via an increase in intracellular cAMP. Agents Actions Suppl. 1986;20:249-57. |
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Chemical & Physical Properties
| Density | 1.47g/cm3 |
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| Molecular Formula | C12H12N4OS |
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| Molecular Weight | 260.31 |
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| Exact Mass | 260.07300 |
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| PSA | 87.52000 |
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| LogP | 1.55830 |
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| Index of Refraction | 1.75 |
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| InChIKey | NPFVRBCDMFKOPY-UHFFFAOYSA-N |
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| SMILES | CC1CC(=O)NN=C1c1cc(-n2ccnc2)cs1 |
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Synonyms
| Motapizone |
| UNII-C4A61P8A37 |
| Motapizonum |
| Motapizona |
| Motapizon |
