CAS 540-23-8|4-Methylaniline hydrochloride
Introduction：Basic information about CAS 540-23-8|4-Methylaniline hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Methylaniline hydrochloride | ||
|---|---|---|---|
| CAS Number | 540-23-8 | Molecular Weight | 143.61400 |
| Density | / | Boiling Point | 200.4ºC |
| Molecular Formula | C7H10ClN | Melting Point | 243-245 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | p-Toluidine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Boiling Point | 200.4ºC |
|---|---|
| Melting Point | 243-245 °C(lit.) |
| Molecular Formula | C7H10ClN |
| Molecular Weight | 143.61400 |
| Exact Mass | 143.05000 |
| PSA | 26.02000 |
| LogP | 2.96040 |
| InChIKey | JQKBUTDZZRGQDR-UHFFFAOYSA-N |
| SMILES | Cc1ccc(N)cc1.Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1285 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 167,223,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 265 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 399 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 86 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83316 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 85 (estimated)
Safety Information
| Symbol | GHS06, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H317-H319-H331-H351-H400 |
| Precautionary Statements | P261-P273-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic;N: Dangerous for the environment; |
| Risk Phrases | R23/24/25;R36;R40;R43;R50 |
| Safety Phrases | S28-S36/37-S45-S61 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | XU7525000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 2921430090 |
Customs
| HS Code | 2921430090 |
|---|---|
| Summary | HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles26
More Articles| Exposure of hairdressers to ortho- and meta-toluidine in hair dyes. Occup. Environ. Med. 72(1) , 57-63, (2015) Carcinogenic aromatic amines derived from hair dyes have recently received new attention. One of these is ortho (o)-toluidine, which is classified as carcinogenic to humans.To clarify exposure of hair... | |
| Two-dimensional fluorometry coupled with artificial neural networks: a novel method for on-line monitoring of complex biological processes. Biotechnol. Bioeng. 72(3) , 297-306, (2001) The use of two-dimensional scanning fluorometry as an on-line, noninvasive, in situ bioreactor monitoring technique is extended to complex bioprocesses using mixed cultures, with particular attention ... | |
| First representative of optically active P-L-menthyl-substituted (aminomethyl)phosphine and its borane and metal complexes. Inorg. Chem. 49(12) , 5407-12, (2010) The first representative of 1,5-diaza-3,7-diphosphacyclooctanes (1) with chiral L-menthyl substituents on the phosphorus atoms was obtained by condensation of L-menthylphosphine with formaldehyde and ... |
Synonyms
| 4-Methylaniline hydrochloride |
| EINECS 208-740-8 |
| MFCD00035497 |
| 4-methylaniline,hydrochloride |
| p-Toluidine Hydrochloride |
