CAS 144-75-2|Aldesulfone Sodium

Introduction：Basic information about CAS 144-75-2|Aldesulfone Sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Aldesulfone Sodium BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Aldesulfone Sodium
CAS Number	144-75-2	Molecular Weight	448.44500
Density	/	Boiling Point	857.3ºC at 760 mmHg
Molecular Formula	C₁₄H₁₄N₂Na₂O₆S₃	Melting Point	/
MSDS	/	Flash Point	472.3ºC

Names

Name	disodium,[4-[4-(sulfinatomethylamino)phenyl]sulfonylanilino]methanesulfinate
Synonym	More Synonyms

Aldesulfone Sodium BiologicalActivity

Description	Sulfoxone (Aldesulfone) disodium is an orally active sulphonamide antibiotic that is used against leprosy. Sulfoxone disodium can also be used in study of dermatitis herpetiformis[1][2].
Related Catalog	Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial

Chemical & Physical Properties

Boiling Point	857.3ºC at 760 mmHg
Molecular Formula	C₁₄H₁₄N₂Na₂O₆S₃
Molecular Weight	448.44500
Flash Point	472.3ºC
Exact Mass	447.98100
PSA	185.26000
LogP	3.97460
Vapour Pressure	2.64E-31mmHg at 25°C
InChIKey	AZBNFLZFSZDPQF-UHFFFAOYSA-L
SMILES	O=S([O-])CNc1ccc(S(=O)(=O)c2ccc(NCS(=O)[O-])cc2)cc1.[Na+].[Na+]
Stability	Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB0390100

CHEMICAL NAME :: Methanesulfinic acid, (sulfonylbis(p-phenyleneimino))di-, disodium salt

CAS REGISTRY NUMBER :: 144-75-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H14-N2-O6-S3.2Na

MOLECULAR WEIGHT :: 448.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 70,1268,1948

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 61,617,1939

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18900 mg/kg/21D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

Safety Information

HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Sodium sulfoxone

Aldapsone

Diazon

(4,4'-sulfonyl-dianilino)-bis-methanesulfinic acid,disodium-salt

Adesulfone sodium

(4,4'-Sulfonyl-dianilino)-bis-methansulfinsaeure,Dinatrium-Salz

Diamidin

Novotrone

Aldesulfone [Sodium]

SULFOXONE SODIUM

Diasone

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