Introduction：Basic information about CAS 73090-70-7|EPIROPRIM, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | EPIROPRIM |
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| CAS Number | 73090-70-7 | Molecular Weight | 353.41800 |
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| Density | 1.27g/cm3 | Boiling Point | 626.5ºC at 760 mmHg |
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| Molecular Formula | C19H23N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | 332.7ºC |
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Names
| Name | 5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine |
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| Synonym | More Synonyms |
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EPIROPRIM BiologicalActivity
| Description | Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81. |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Boiling Point | 626.5ºC at 760 mmHg |
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| Molecular Formula | C19H23N5O2 |
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| Molecular Weight | 353.41800 |
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| Flash Point | 332.7ºC |
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| Exact Mass | 353.18500 |
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| PSA | 101.21000 |
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| LogP | 3.98230 |
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| Index of Refraction | 1.629 |
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| InChIKey | NMARPFMJVCXSAV-UHFFFAOYSA-N |
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| SMILES | CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UV8140650
- CHEMICAL NAME :
- 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-
- CAS REGISTRY NUMBER :
- 73090-70-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H23-N5-O2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1419 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993
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Synonyms
| Ro 11-8958 |
| 2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl) |
| Epiroprima [INN-Spanish] |
| 5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine |
| Epiroprimum [INN-Latin] |
| Epiroprime [INN-French] |
| Epiroprim |
