Introduction：Basic information about CAS 910297-51-7|N-Deshydroxyethyl Dasatinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-Deshydroxyethyl Dasatinib |
|---|
| CAS Number | 910297-51-7 | Molecular Weight | 443.95300 |
|---|
| Density | 1.404g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C20H22ClN7OS | Melting Point | >300ºC |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide |
|---|
| Synonym | More Synonyms |
|---|
N-Deshydroxyethyl Dasatinib BiologicalActivity
| Description | Target Protein-binding moiety 8 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity. |
|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblSignaling Pathways >>PROTAC >>PROTACResearch Areas >>Cancer |
|---|
| Target | BCR-ABL[1] |
|---|
| In Vitro | Target Protein-binding moiety 8 (Compound 8) is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity. |
|---|
| References | [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. |
|---|
Chemical & Physical Properties
| Density | 1.404g/cm3 |
|---|
| Melting Point | >300ºC |
|---|
| Molecular Formula | C20H22ClN7OS |
|---|
| Molecular Weight | 443.95300 |
|---|
| Exact Mass | 443.13000 |
|---|
| PSA | 123.31000 |
|---|
| LogP | 4.14860 |
|---|
| Index of Refraction | 1.69 |
|---|
| InChIKey | DOBZFFWLHXORTB-UHFFFAOYSA-N |
|---|
| SMILES | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCNCC2)n1 |
|---|
Synonyms
| N-(2-CHLORO-6-METHYLPHENYL)-2-[[2-METHYL-6-(PIPERAZIN-1-YL)-PYRIMIDIN-4-YL]AMINO]-5-THIAZOLECARBOXAMIDE |
| Dasatinib metabolite M4 |
| N-(2-chloro-6-methylphenyl)-2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-5-carboxamide |
| N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| N-Deshydroxyethyl Dasatinib |
| Dasatinib Impurity 6 |
| Target Protein-binding moiety 8 |
