CAS 54556-98-8|Propiverine hydrochloride
Introduction：Basic information about CAS 54556-98-8|Propiverine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Propiverine hydrochloride | ||
|---|---|---|---|
| CAS Number | 54556-98-8 | Molecular Weight | 403.942 |
| Density | / | Boiling Point | 494.7ºC at 760 mmHg |
| Molecular Formula | C23H30ClNO3 | Melting Point | 213-216ºC |
| MSDS | ChineseUSA | Flash Point | 253ºC |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | Propiverine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Propiverine hydrochloride BiologicalActivity
| Description | Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease |
| In Vitro | Propiverine (10-3000 nM) inhibits the specific binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2]. |
| In Vivo | Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats[1]. Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo[1]. Animal Model: Female adult Sprague-Dawley rats (250-270 g)[1] Dosage: 5 mg dissolved in distilled water (0.5 mL) Administration: P.o. once daily for 2 weeks Result: Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly. Increased plasma epinephrine and norepinephrine levels. No significant changes were observed in body weight. |
| References | [1]. Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8. [2]. Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9. |
Chemical & Physical Properties
| Boiling Point | 494.7ºC at 760 mmHg |
|---|---|
| Melting Point | 213-216ºC |
| Molecular Formula | C23H30ClNO3 |
| Molecular Weight | 403.942 |
| Flash Point | 253ºC |
| Exact Mass | 403.191437 |
| PSA | 38.77000 |
| LogP | 4.73410 |
| InChIKey | KFUJMHHNLGCTIJ-UHFFFAOYSA-N |
| SMILES | CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1.Cl |
| Storage condition | -20°C Freezer |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18200 mg/kg/1Y-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Liver - changes in liver weight Endocrine - changes in pituitary weight
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15,107,1990 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - other neonatal measures or effects
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 37/38-41 |
| Safety Phrases | 26-39 |
| RIDADR | NONH for all modes of transport |
| RTECS | AH3297000 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles24
More Articles| Excitatory effect of propiverine hydrochloride on urethral activity in rats. Int. J. Urol. 19(6) , 575-82, (2012) To investigate the effects of the antimuscarinic agent, propiverine, on the bladder and urethra in rats.A total of 54 female rats were given propiverine, imidafenacin (an antimuscarinic agent), or dis... | |
| [Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy]. Hinyokika Kiyo. 57(2) , 71-6, (2011) The efficacy and safety of additional administration of propiverine were prospectively studied for naftopidil-resistant nocturia in patients with benign prostatic hypertrophy (BPH). Patients of 50 yea... | |
| An overview on mixed action drugs for the treatment of overactive bladder and detrusor overactivity. Urol. Int. 89(3) , 259-69, (2012) To provide an overview on the efficacy, tolerability, safety and health-related quality of life (HRQoL) of drugs with a mixed action used in the treatment of overactive bladder (OAB).MEDLINE database ... |
Synonyms
| Mictonetten |
| Mictonorm |
| Propiverine hydrochloride |
| Propiverine Hydrochlorride |
| 1-Methyl-4-piperidinyl diphenyl(propoxy)acetate hydrochloride (1:1) |
| Propiverine HCl |
| UNII-DC4GZD10H3 |
| Benzeneacetic acid, α-phenyl-α-propoxy-, 1-methyl-4-piperidinyl ester, hydrochloride (1:1) |
| 1-Methylpiperidin-4-yl diphenyl(propoxy)acetate hydrochloride (1:1) |
