Introduction：Basic information about CAS 19249-03-7|Triethylene glycol bis(p-toluenesulfonate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Triethylene glycol bis(p-toluenesulfonate) |
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| CAS Number | 19249-03-7 | Molecular Weight | 458.546 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 608.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O8S2 | Melting Point | 78-82 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 321.7±31.5 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 608.4±55.0 °C at 760 mmHg |
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| Melting Point | 78-82 °C(lit.) |
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| Molecular Formula | C20H26O8S2 |
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| Molecular Weight | 458.546 |
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| Flash Point | 321.7±31.5 °C |
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| Exact Mass | 458.106903 |
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| PSA | 121.96000 |
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| LogP | 2.34 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.545 |
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| InChIKey | KCONMNWPRXAWKK-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2909309090 |
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Customs
| HS Code | 2909309090 |
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| Summary | 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Articles1
More Articles
| G.W. Gokel, S.H. Korzeniowski Macrocyclic Polyether Synthesis , (1982)
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Synonyms
| Ethanol, 2,2'-(1,2-ethanediylbis(oxy))bis-, bis(4-methylbenzenesulfonate) |
| 1,2-Ethanediylbis(oxy-2,1-ethanediyl) bis(4-methylbenzenesulfonate) |
| 2-[2-(2-([(4-Methylphenyl)sulfonyl]oxy)ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate |
| TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE |
| ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| Triethylene Glycol Bis(p-toluenesulfonate) |
| TsOCH2(CH2OCH2)2CH2OTs |
| Triethylene glycol di(p-toluenesulfonate) |
| Triethylene Glycol Di-p-tosylate |
| triethylene glycol bis(4-toluenesulfonate) |
| 1,2-Bis(2-tosyloxyethoxy)ethane |
| Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) |
| bis-tosylated triethyleneglycol |
| MFCD00048096 |
| Triethylene glycol ditosylate |
| 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane |
| 2,2'-(Ethylenedioxy)diethyl Ditosylate |
| (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| 2-(2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfon ate |
| Tos-PEG4-Tos |
