Introduction：Basic information about CAS 90-34-6|Primaquine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Primaquine |
|---|
| CAS Number | 90-34-6 | Molecular Weight | 259.347 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 451.1±45.0 °C at 760 mmHg |
|---|
| Molecular Formula | C15H21N3O | Melting Point | 25°C |
|---|
| MSDS | / | Flash Point | 226.6±28.7 °C |
|---|
Names
| Name | primaquine |
|---|
| Synonym | More Synonyms |
|---|
Primaquine BiologicalActivity
| Description | Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria[1][2]. |
|---|
| Related Catalog | Research Areas >>Infection |
|---|
| References | [1]. Baird JK, et al. Primaquine therapy for malaria. Clin Infect Dis. 2004 Nov 1;39(9):1336-45. [2]. Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418. |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 451.1±45.0 °C at 760 mmHg |
|---|
| Melting Point | 25°C |
|---|
| Molecular Formula | C15H21N3O |
|---|
| Molecular Weight | 259.347 |
|---|
| Flash Point | 226.6±28.7 °C |
|---|
| Exact Mass | 259.168457 |
|---|
| PSA | 60.17000 |
|---|
| LogP | 2.67 |
|---|
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.616 |
|---|
| InChIKey | INDBQLZJXZLFIT-UHFFFAOYSA-N |
|---|
| SMILES | COc1cc(NC(C)CCCN)c2ncccc2c1 |
|---|
| Storage condition | 2-8°C |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VA9650000
- CHEMICAL NAME :
- Quinoline, 8-(4-amino-1-methylbutylamino)-6-methoxy-
- CAS REGISTRY NUMBER :
- 90-34-6
- BEILSTEIN REFERENCE NO. :
- 0019337
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C15-H21-N3-O
- MOLECULAR WEIGHT :
- 259.39
- WISWESSER LINE NOTATION :
- T66 BNJ HO1 JMY1&3Z
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 68800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 96 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 810 mg/kg/3W-I
- TOXIC EFFECTS :
- Behavioral - ataxia Liver - hepatitis (hepatocellular necrosis), zonal Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 283 mg/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 336 mg/kg/16D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 8 mg/kg
- REFERENCE :
- SYXUD2 Shandong Yixueyuan Xuebao. Journal of Shandong Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 23,26,1985
|
Safety Information
| Hazard Codes | Xn |
|---|
| HS Code | 2933499090 |
|---|
Customs
| HS Code | 2933499090 |
|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| (±)-Primaquine |
| [14C]-Primaquine |
| 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)- (9CI) |
| Primaquine |
| 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine |
| N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine |
| Primaquin |
| Primachinum |
| 1,4-Pentanediamine, N4- (6-methoxy-8-quinolinyl)- |
| N-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine |
| 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline |
| 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)- |
| Neo-Quipenyl |
| 1,4-Pentanediamine, N(4)-(6-methoxy-8-quinolinyl)- |
| 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline |
| N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine |
| EINECS 201-987-2 |
| Primaquinum |
| N-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine |
| UNII:MVR3634GX1 |
| Primachin |
| Primaquina |
| 6-Methoxy-8-[(4-amino-1-methylbutyl)amino]quinoline |
| N'-(6-methoxy-8-quinolinyl)-1,4-pentanediamine |
| 1,4-Pentanediamine, N-(6-methoxy-8-quinolinyl)- |
| N-[6-(methyloxy)quinolin-8-yl]pentane-1,4-diamine |
