Introduction：Basic information about CAS 5452-87-9|Betahistine EP Impurity C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Betahistine EP Impurity C |
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| CAS Number | 5452-87-9 | Molecular Weight | 241.33100 |
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| Density | 1.067g/cm3 | Boiling Point | 371.9ºC at 760mmHg |
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| Molecular Formula | C15H19N3 | Melting Point | / |
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| MSDS | / | Flash Point | 178.7ºC |
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Names
| Name | N-Methyl-N,N-bis(2-pyridylethyl)amine |
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| Synonym | More Synonyms |
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Betahistine EP Impurity C BiologicalActivity
| Description | Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| In Vitro | Betahistine (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively[3]. |
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| References | [1]. Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019 [2]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3. [3]. Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2]. |
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Chemical & Physical Properties
| Density | 1.067g/cm3 |
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| Boiling Point | 371.9ºC at 760mmHg |
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| Molecular Formula | C15H19N3 |
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| Molecular Weight | 241.33100 |
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| Flash Point | 178.7ºC |
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| Exact Mass | 241.15800 |
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| PSA | 29.02000 |
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| LogP | 2.19360 |
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| Index of Refraction | 1.568 |
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| InChIKey | PQHKIDBZBKQYMR-UHFFFAOYSA-N |
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| SMILES | CN(CCc1ccccn1)CCc1ccccn1 |
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| Storage condition | -20℃ |
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| N-methyl-2-pyridin-2-yl-N-(2-pyridin-2-ylethyl)ethanamine |
| NSC19005 |
