CAS 112-60-7|2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
Introduction：Basic information about CAS 112-60-7|2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol | ||
|---|---|---|---|
| CAS Number | 112-60-7 | Molecular Weight | 194.225 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 328.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H18O5 | Melting Point | -5.6 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 176.7±0.0 °C |
Names
| Name | tetraethylene glycol |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 328.0±0.0 °C at 760 mmHg |
| Melting Point | -5.6 °C(lit.) |
| Molecular Formula | C8H18O5 |
| Molecular Weight | 194.225 |
| Flash Point | 176.7±0.0 °C |
| Exact Mass | 194.115417 |
| PSA | 68.15000 |
| LogP | -2.23 |
| Vapour density | 6.7 (vs air) |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.455 |
| InChIKey | UWHCKJMYHZGTIT-UHFFFAOYSA-N |
| SMILES | OCCOCCOCCOCCO |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Water Solubility | soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28900 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0987-0693 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84662 No. of Facilities: 206 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 1685 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84662 No. of Facilities: 3704 (estimated) No. of Industries: 40 No. of Occupations: 44 No. of Employees: 55282 (estimated) No. of Female Employees: 1585 (estimated)
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0987-0693 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84662 No. of Facilities: 206 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 1685 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84662 No. of Facilities: 3704 (estimated) No. of Industries: 40 No. of Occupations: 44 No. of Employees: 55282 (estimated) No. of Female Employees: 1585 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
|---|---|
| Hazard Codes | C |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XC2100000 |
| HS Code | 2942000000 |
Customs
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| 2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol |
| 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol |
| Tetra(ethylene glycol) |
| 2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol |
| MFCD00002879 |
| Tetraglycol |
| Ethyl acetate |
| Tetraethylene glycol |
| 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol |
| EINECS 203-989-9 |
| Bis[2-(2-hydroxyethoxy)ethyl] ether |
| Bis[2-(2-hydroxyethoxy)ethyl]ether |
| tetraethylene glycol- |
| tetraethyleneglycol |
| Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis- |
| PEG-4 |
