CAS 4026-18-0|2-Hydroxy-3-methylbutyric acid
| Common Name | 2-Hydroxy-3-methylbutyric acid | ||
|---|---|---|---|
| CAS Number | 4026-18-0 | Molecular Weight | 118.131 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 237.6±13.0 °C at 760 mmHg |
| Molecular Formula | C5H10O3 | Melting Point | 86-87ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 111.8±16.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-hydroxy-3-methylbutyric acid |
|---|---|
| Synonym | More Synonyms |
2-Hydroxy-3-methylbutyric acid BiologicalActivity
| Description | 2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive drug. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Neurological Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Pan YM, et al. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001 Jul-Aug;25(5):328-32. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 237.6±13.0 °C at 760 mmHg |
| Melting Point | 86-87ºC(lit.) |
| Molecular Formula | C5H10O3 |
| Molecular Weight | 118.131 |
| Flash Point | 111.8±16.3 °C |
| Exact Mass | 118.062996 |
| PSA | 57.53000 |
| LogP | 0.18 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.455 |
| InChIKey | NGEWQZIDQIYUNV-UHFFFAOYSA-N |
| SMILES | CC(C)C(O)C(=O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918199090 |
Customs
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles30
More Articles| Physiology and pathophysiology of organic acids in cerebrospinal fluid. J. Inherit. Metab. Dis. 16(4) , 648-69, (1993) Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo... | |
| α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain Brain Res. 1324 , 75-84, (2010) Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathoiphysiology is poorly known. In the present study we investigated the in ... | |
| Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease. J. Inherit. Metab. Dis. 22(6) , 706-22, (1999) In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex ... |
Synonyms
| D-Valic acid |
| D-2-HYDROXY-3-METHYLBUTYRIC ACID |
| A-hydroxyisovaleric acid |
| DL-2-Hydroxyisovaleric acid |
| 2-HYDROXY-3-METHYLBU |
| α-hydroxyisovaleric acid |
| MFCD00004242 |
| Einecs 223-697-5 |
| UNII:02X1W97FWN |
| DL-a-hydroxyisovaleric acid |
| L-2-hydroxyisovaleric acid |
| 2-hydroxy-3-methyl-Butyric acid |
| 2-Oxyisovaleric Acid |
| 2-Hydroxy-3-methylbutanoic acid |
| DL-2-Hydroxy-3-methylbutanoic acid |
| 2-Hydroxy-3-methylbutyric acid |
| 3-Methyl-2-hydroxybutyric acid |
| Butanoic acid, 2-hydroxy-3-methyl- |
| 2-Hydroxy-3-methylbutyricAcid |
| 2-Hydroxyisopentanoic acid |
| 2-hydroxy-3-Methyl |
| (2S)-2-Hydroxy-3-methylbutanoic acid |
| 2-hydroxyisovaleric acid |
| DL-α-hydroxyisovaleric acid |
| D-a-Hydroxyisovaleric acid |
| Butanoic acid, 2-hydroxy-3-methyl-, (2S)- |
| 2-hydroxy-3-methyl butyric acid |
