Introduction：Basic information about CAS 141699-55-0|1-N-Boc-3-hydroxyazetidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-N-Boc-3-hydroxyazetidine |
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| CAS Number | 141699-55-0 | Molecular Weight | 173.210 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 253.7±33.0 °C at 760 mmHg |
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| Molecular Formula | C8H15NO3 | Melting Point | 42-44°C |
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| MSDS | ChineseUSA | Flash Point | 107.2±25.4 °C |
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| Symbol |
GHS05, GHS07 | Signal Word | Danger |
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Names
| Name | 1-Boc-3-hydroxyazetidine |
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| Synonym | More Synonyms |
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1-N-Boc-3-hydroxyazetidine BiologicalActivity
| Description | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 253.7±33.0 °C at 760 mmHg |
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| Melting Point | 42-44°C |
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| Molecular Formula | C8H15NO3 |
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| Molecular Weight | 173.210 |
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| Flash Point | 107.2±25.4 °C |
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| Exact Mass | 173.105194 |
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| PSA | 49.77000 |
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| LogP | -0.17 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.511 |
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| InChIKey | XRRXRQJQQKMFBC-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)N1CC(O)C1 |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS05, GHS07 |
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| Signal Word | Danger |
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| Hazard Statements | H302-H315-H318-H335 |
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| Precautionary Statements | P261-P280-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi,Xn |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36/37/39 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-N-Boc-3-hydroxyazetidine |
| 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine |
| MFCD04115305 |
| tert-Butyl 3-Hydroxyazetidine-1-carboxylate |
| 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester |
| 1-BOC-3-Hydroxyazetidine |
| N-Boc-3-hydroxyazetidine |
