Introduction：Basic information about CAS 114676-69-6|N-Boc-cis-4-hydroxy-D-proline methyl ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-Boc-cis-4-hydroxy-D-proline methyl ester |
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| CAS Number | 114676-69-6 | Molecular Weight | 245.27200 |
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| Density | 1.216g/cm3 | Boiling Point | 335.2ºC at 760mmHg |
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| Molecular Formula | C11H19NO5 | Melting Point | 80 °C |
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| MSDS | / | Flash Point | 156.6ºC |
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Names
| Name | Methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.216g/cm3 |
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| Boiling Point | 335.2ºC at 760mmHg |
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| Melting Point | 80 °C |
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| Molecular Formula | C11H19NO5 |
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| Molecular Weight | 245.27200 |
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| Flash Point | 156.6ºC |
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| Exact Mass | 245.12600 |
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| PSA | 76.07000 |
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| LogP | 0.46760 |
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| Appearance of Characters | Powder | White |
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| Vapour Pressure | 8.47E-06mmHg at 25°C |
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| Index of Refraction | 1.5 |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-O-tert-butyl 2-O-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate |
| Methyl Cis-1-Boc-4-Hydroxy-D-Prolinate |
| N-Boc-cis-4-hydroxy-D-proline methyl ester |
