CAS 142347-81-7|tans-4-Hydroxy-D-proline hydrochloride

Introduction：Basic information about CAS 142347-81-7|tans-4-Hydroxy-D-proline hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. tans-4-Hydroxy-D-proline hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	tans-4-Hydroxy-D-proline hydrochloride
CAS Number	142347-81-7	Molecular Weight	167.591
Density	/	Boiling Point	368.6ºC at 760mmHg
Molecular Formula	C₅H₁₀ClNO₃	Melting Point	/
MSDS	/	Flash Point	176.7ºC

Names

Name	trans-4-Hydroxy-D-proline hydrochloride
Synonym	More Synonyms

tans-4-Hydroxy-D-proline hydrochloride BiologicalActivity

Description	tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Boiling Point	368.6ºC at 760mmHg
Molecular Formula	C₅H₁₀ClNO₃
Molecular Weight	167.591
Flash Point	176.7ºC
Exact Mass	167.034927
PSA	69.56000
Vapour Pressure	6.22E-07mmHg at 25°C
InChIKey	YEJFFQAGTXBSTI-RFKZQXLXSA-N
SMILES	Cl.O=C(O)C1CC(O)CN1

Safety Information

Hazard Codes	Xi

Synonyms

(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

D-Proline, 1-hydroxy-, hydrochloride (1:1)

trans-4-Hydroxy-D-proline Hydrochloride

1-Hydroxy-D-proline hydrochloride (1:1)

(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride

trans-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

(4S)-4-Hydroxy-D-proline hydrochloride (1:1)

D-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1)

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