Introduction：Basic information about CAS 40216-83-9|H-Hyp-OMe hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Hyp-OMe hydrochloride |
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| CAS Number | 40216-83-9 | Molecular Weight | 181.617 |
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| Density | / | Boiling Point | 247.2ºC at 760 mmHg |
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| Molecular Formula | C6H12ClNO3 | Melting Point | / |
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| MSDS | USA | Flash Point | 103.3ºC |
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Names
| Name | (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride |
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| Synonym | More Synonyms |
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H-Hyp-OMe hydrochloride BiologicalActivity
| Description | H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]< |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Boiling Point | 247.2ºC at 760 mmHg |
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| Molecular Formula | C6H12ClNO3 |
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| Molecular Weight | 181.617 |
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| Flash Point | 103.3ºC |
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| Exact Mass | 181.050568 |
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| PSA | 58.56000 |
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| LogP | 0.01300 |
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| InChIKey | KLGSHNXEUZOKHH-JBUOLDKXSA-N |
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| SMILES | COC(=O)C1CC(O)CN1.Cl |
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| Storage condition | 2-8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi: Irritant; |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1) |
| Trans-4-hydroxy-L-proline methyl ester hydrochloride |
| Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) |
| L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1) |
| Trans-4-Hydroxy-L-Proline Methyl Ester,Hydrochloride Salt |
| (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride |
| Methyl 4-hydroxyprolinate hydrochloride (1:1) |
| L-4-Hydroxyproline methyl ester hydrochloride |
| Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate |
| Methyl (2S,4R)-4-Hydroxypyrrolidine-2-carboxylate Hydrochloride |
| H-Hyp-OMe·HCl |
| methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride |
| MFCD00080855 |
| H-Hyp-OMe．HCl |
| trans-4-Hydroxy-L-proline methylester hydrochloride |
