CAS 1406-18-4|Tocopherol
Introduction：Basic information about CAS 1406-18-4|Tocopherol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tocopherol | ||
|---|---|---|---|
| CAS Number | 1406-18-4 | Molecular Weight | 490.61600 |
| Density | 0.93 g/cm3 | Boiling Point | 210ºC at 0.1 mm Hg |
| Molecular Formula | C24H34N4O5S | Melting Point | 3ºC |
| MSDS | / | Flash Point | 210.2ºC |
Names
| Name | Tocopherol |
|---|---|
| Synonym | More Synonyms |
Tocopherol BiologicalActivity
| Description | Vitamin E, an essential nutrient for humans and animals reproduction, is a lipid-soluble antioxidant. Vitamin E can protect lipids against oxidative stress, and rescue the glutathione (GSH) depletion-induced hypersensitivity of cells to H2O2. Supplementation with Vitamin E increases its levels in cerebrospinal fluid and plasma, as well as reduces Aβ levels, thus beneficially influences oxidative stress in Alzheimer's disease. Vitamin E also has anti-aging effects[1][2][3][4]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease |
| Target | ROS, Amyloid-β[1][4] |
| In Vitro | Vitamin E (5-80 μM) rescues the GSH depletion-induced hypersensitivity of rabbit lens epithelial cells (RLEC) to H2O2[2]. |
| In Vivo | Vitamin E (2 I.U./g diet; PO; daily, for 8 months) suppresses brain lipid peroxidation and significantly reduces Aβ levels and amyloid plaque deposition[4]. Animal Model: Tg2576 mice (transgenic model of Alzheimer's disease)[4] Dosage: 2 I.U./g diet Administration: PO; daily, for 8 months (from 5 month-old to 13 month-old) Result: Suppressed brain lipid peroxidation and significantly reduces Aβ levels and amyloid plaque deposition when it is administered early during the evolution of their disease phenotype. |
| References | [1]. Traber MG, et al. Vitamin E, antioxidant and nothing more. Free Radic Biol Med. 2007 Jul 1;43(1):4-15. [2]. Shang F, et al. Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2. Free Radic Biol Med. 2003 Mar 1;34(5):521-30. [3]. Kontush K, et al. Vitamin E in neurodegenerative disorders: Alzheimer's disease. Ann N Y Acad Sci. 2004 Dec;1031:249-62. [4]. Sung S, et al. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. FASEB J. 2004 Feb;18(2):323-5. |
Chemical & Physical Properties
| Density | 0.93 g/cm3 |
|---|---|
| Boiling Point | 210ºC at 0.1 mm Hg |
| Melting Point | 3ºC |
| Molecular Formula | C24H34N4O5S |
| Molecular Weight | 490.61600 |
| Flash Point | 210.2ºC |
| Exact Mass | 490.22500 |
| PSA | 133.06000 |
| LogP | 5.26540 |
| InChIKey | GVJHHUAWPYXKBD-UQIPPQJZSA-N |
| SMILES | Cc1c(C)c2c(c(C)c1O)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2 |
| Storage condition | 0-6°C |
Synonyms
| EINECS 215-798-8 |
| MFCD00072051 |
