Introduction：Basic information about CAS 142001-63-6|Saredutant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Saredutant |
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| CAS Number | 142001-63-6 | Molecular Weight | 552.53400 |
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| Density | 1.26g/cm3 | Boiling Point | 734.7ºC at 760mmHg |
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| Molecular Formula | C31H35Cl2N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | 398.1ºC |
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Names
| Name | N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide |
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| Synonym | More Synonyms |
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Saredutant BiologicalActivity
| Description | Saredutant is a selective NK2 receptor antagonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Neurokinin ReceptorSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological Disease |
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| Target | NK2 |
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| In Vivo | Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility[1]. |
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| Animal Admin | Rats[1] In the first experiment the dose-related effects of Saredutant are investigated. The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following: vehicle (carboxymethylcellulose-CMC) or 1, 3, or 10 mg/kg Saredutant, or 5 mg/kg Desipramine as a positive control. Saredutant is injected at 1 mL/kg. The Flinders Resistant Line (FRL) rats are given CMC or 3 mg/kg Saredutant. All injections are i.p. and are given for 14 consecutive days. Approximately 22 h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording. Then about 2 h later the rats are individually tested in the forced swim test for a single 5-min session[1]. |
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| References | [1]. Overstreet DH, et al. Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with Desipramine in an animal model of depression. Pharmacol Biochem Behav. 2010 Aug;96(2):206-10. |
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Chemical & Physical Properties
| Density | 1.26g/cm3 |
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| Boiling Point | 734.7ºC at 760mmHg |
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| Molecular Formula | C31H35Cl2N3O2 |
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| Molecular Weight | 552.53400 |
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| Flash Point | 398.1ºC |
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| Exact Mass | 551.21100 |
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| PSA | 52.65000 |
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| LogP | 6.69550 |
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| Vapour Pressure | 1.91E-21mmHg at 25°C |
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| Index of Refraction | 1.628 |
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| InChIKey | PGKXDIMONUAMFR-AREMUKBSSA-N |
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| SMILES | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 |
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Synonyms
