Introduction：Basic information about CAS 9007-43-6|Cytochrome C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis[1].
Related Catalog
Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Metabolic Disease
In Vitro
哺乳动物 Cytochrome C 在健康状态下清除活性氧 (ROS)，在凋亡过程中与辅因子 p66Shc 产生 ROS，氧化心磷脂[1]。
References
[1]. Hüttemann M, et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 2011 May;11(3):369-81.
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
20 ug/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981
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Synonyms
Cytochromert
EINECS 232-700-9
myohematin
Cytor-est
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis[1-[[2-amino-3-(methylamino)-3-oxopropyl]thio]ethyl]-3,8,13,17-tetramethyl-, iron(2+) salt (1:1)
