Introduction：Basic information about CAS 9064-57-7|GAMMA-CARRAGEENAN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent[1].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In Vivo
λ-Carrageenan (50 mg/kg every two days; intratumoral injection) inhibits tumor growth in B16-F10 and 4T1 bearing mice[1]. λ-carrageenan exhibits considerable antitumor effect via intratumoral injection and significantly improves the tumor immune response with increased infiltrates of immunostimulating cells and increases production of proinflammatory cytokines[1].
References
[1]. Luo M, et al. Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy. Sci Rep. 2015;5:11062. Published 2015 Jun 22.
Vascular - thrombosis distant from injection site Liver - hepatitis (hepatocellular necrosis), zonal Liver - other changes
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 57,455,1976
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 17,647,1965
Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in order to control cell behavior. Platelet lysate (PL) presents itself as a cost-effective source of multiple GFs ...
Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics.
Carbohydr. Polym. 123 , 339-49, (2015)
The aim of this work was to investigate the feasibility of cross-linker free polyelectrolyte complex formation at the nanoscale between carrageenan (CAR) and protamine (PROT). The properties of CAR/PR...
Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.
J. Nat. Prod. 75 , 54-59, (2012)
Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food industries. Lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the λ-carrageenan-induced edema mouse paw mod...
