CAS 86307-44-0|pre-Calcitriol PTAD Adduct

Introduction：Basic information about CAS 86307-44-0|pre-Calcitriol PTAD Adduct, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. pre-Calcitriol PTAD Adduct BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	pre-Calcitriol PTAD Adduct
CAS Number	86307-44-0	Molecular Weight	591.78100
Density	/	Boiling Point	/
Molecular Formula	C₃₅H₄₉N₃O₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	pre-Calcitriol PTAD Adduct
Synonym	More Synonyms

pre-Calcitriol PTAD Adduct BiologicalActivity

Description	Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Related Catalog	Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Cancer
References	[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. [3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23. [4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

Description

Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Related Catalog

Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Cancer

References

[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)

[2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.

[3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.

[4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

Chemical & Physical Properties

Molecular Formula	C₃₅H₄₉N₃O₅
Molecular Weight	591.78100
Exact Mass	591.36700
PSA	109.62000
LogP	5.05860
InChIKey	AYDPRRXRNSGAGP-SOWNFDNZSA-N
SMILES	CC1=C(C2C=C3C(CCC4(C)C3CCC4C(C)CCCC(C)(C)O)n3c(=O)n(-c4ccccc4)c(=O)n32)CC(O)CC1O
Storage condition	2-8℃

Synonyms

Impurity C of Calcitriol

Calcitriol Impurity 3

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