CAS 917369-31-4|MPC 6827 hydrochloride
Introduction：Basic information about CAS 917369-31-4|MPC 6827 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MPC 6827 hydrochloride | ||
|---|---|---|---|
| CAS Number | 917369-31-4 | Molecular Weight | 315.79700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C17H18ClN3O | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride (1:1) |
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MPC 6827 hydrochloride BiologicalActivity
| Description | Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
| Target | microtubule[1] |
| References | [1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71. [2]. Sirisoma N, et al. Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J Med Chem. 2009 Apr 23;52(8):2341-51. |
Chemical & Physical Properties
| Molecular Formula | C17H18ClN3O |
|---|---|
| Molecular Weight | 315.79700 |
| Exact Mass | 315.11400 |
| PSA | 38.25000 |
| LogP | 4.51670 |
| InChIKey | VYUWDIKZJLOZJL-UHFFFAOYSA-N |
| SMILES | COc1ccc(N(C)c2nc(C)nc3ccccc23)cc1.Cl |
