Introduction：Basic information about CAS 875634-01-8|PPY A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PPY A |
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| CAS Number | 875634-01-8 | Molecular Weight | 372.42000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H20N4O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethy lnicotinamide |
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PPY A BiologicalActivity
| Description | PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba⁄F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-Abl |
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| References | [1]. Tianjun Zhou, et al. Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des. 2007 Sep;70(3):171-81. |
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Chemical & Physical Properties
| Molecular Formula | C22H20N4O2 |
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| Molecular Weight | 372.42000 |
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| Exact Mass | 372.15900 |
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| PSA | 71.11000 |
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| LogP | 4.00230 |
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| InChIKey | GYQRHHQPEMOLKH-UHFFFAOYSA-N |
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| SMILES | COc1ccccc1-c1c[nH]c2ncc(-c3cncc(C(=O)N(C)C)c3)cc12 |
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