CAS 67200-34-4|Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one
Introduction：Basic information about CAS 67200-34-4|Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>E1/E2/E3 Enzyme
In Vitro
In yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3[1]. Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCFMet30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels[1].
References
[1]. Mariam Aghajan, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010 Jul;28(7):738-42.
Chemical & Physical Properties
Density
1.7±0.1 g/cm3
Boiling Point
437.2±55.0 °C at 760 mmHg
Melting Point
296 °C(dec.)
Molecular Formula
C11H4N4O2
Molecular Weight
224.175
Flash Point
218.2±31.5 °C
Exact Mass
224.033432
PSA
81.77000
LogP
0.90
Vapour Pressure
0.0±1.0 mmHg at 25°C
Index of Refraction
1.779
InChIKey
SFSSAKVWCKFRHE-UHFFFAOYSA-N
SMILES
O=C1c2ccccc2-c2nc3nonc3nc21
Safety Information
Symbol
GHS07
Signal Word
Warning
Hazard Statements
H302
RIDADR
NONH for all modes of transport
Articles1
More Articles
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.
Nat. Biotechnol. 28 , 738 - 742, (2010)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pat...
