Introduction：Basic information about CAS 159857-80-4|MC-Val-Cit-PAB-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MC-Val-Cit-PAB-OH |
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| CAS Number | 159857-80-4 | Molecular Weight | 572.65300 |
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| Density | 1.276 | Boiling Point | / |
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| Molecular Formula | C28H40N6O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide |
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| Synonym | More Synonyms |
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MC-Val-Cit-PAB-OH BiologicalActivity
| Description | MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. |
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| Related Catalog | Signaling Pathways >>Antibody-drug Conjugate >>ADC LinkerResearch Areas >>Cancer |
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| Target | ADC linker[1] |
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| References | [1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
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Chemical & Physical Properties
| Density | 1.276 |
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| Molecular Formula | C28H40N6O7 |
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| Molecular Weight | 572.65300 |
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| Exact Mass | 572.29600 |
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| PSA | 210.70000 |
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| LogP | 3.27310 |
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| InChIKey | AMKBTTRWLGVRER-OFVILXPXSA-N |
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| SMILES | CC(C)C(NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
