Introduction：Basic information about CAS 400827-55-6|Ceftaroline fosamil acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ceftaroline fosamil acetate |
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| CAS Number | 400827-55-6 | Molecular Weight | 762.752 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H27N8O11PS4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ceftaroline fosamil acetate monohydrate |
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| Synonym | More Synonyms |
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Ceftaroline fosamil acetate BiologicalActivity
| Description | Ceftaroline fosamil hydrate acetate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrate acetate shows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate acetate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP)[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Ceftaroline fosamil hydrate acetate (s.c.) shows protective effects against experimental systemic infection caused by S. aureus N133 in mice, with ED50s of 1.60-2.37 mg/kg[1]. Ceftaroline fosamil hydrate acetate (10 mg/kg; s.c.) disappeares rapidly and converts smoothly into T-91825 in blood of rats and monkeys[1]. |
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| References | [1]. Ishikawa T, et, al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem. 2003 May 29;11(11):2427-37. [2]. Biek D, et al. Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity. J Antimicrob Chemother. 2010 Nov;65 Suppl 4:iv9-16. [3]. Parish D, et al. Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Curr Opin Investig Drugs. 2008 Feb;9(2):201-9. |
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Chemical & Physical Properties
| Molecular Formula | C24H27N8O11PS4 |
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| Molecular Weight | 762.752 |
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| Exact Mass | 762.041992 |
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| PSA | 393.38000 |
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| LogP | 1.88460 |
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| InChIKey | KRWPPVCZNGQQHZ-IINIBMQSSA-N |
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| SMILES | CC(=O)[O-].CCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CSC12)c1nsc(NP(=O)(O)O)n1.O |
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Synonyms
| ceftaroline fosamil acetate monohydrate |
| (6R,7R)-7-({(2Z)-2-(Ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methyl-4-pyridiniumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate acetate hydrate (1:1:1) |
| Ceftaroline fosamil acetate hydrate |
| (6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,acetate,hydrate |
| Ceftaroline fosamil acetate |
