CAS 1127498-03-6|JNJ-40411813

Introduction：Basic information about CAS 1127498-03-6|JNJ-40411813, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. JNJ-40411813 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	JNJ-40411813
CAS Number	1127498-03-6	Molecular Weight	344.87800
Density	/	Boiling Point	/
Molecular Formula	C₂₀H₂₅ClN₂O	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
Synonym	More Synonyms

JNJ-40411813 BiologicalActivity

Description	JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease
References	[1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.

Chemical & Physical Properties

Molecular Formula	C₂₀H₂₅ClN₂O
Molecular Weight	344.87800
Exact Mass	344.16600
PSA	25.24000
LogP	4.75080
InChIKey	HYOGJHCDLQSAHX-UHFFFAOYSA-N
SMILES	CCCCn1ccc(N2CCC(c3ccccc3)CC2)c(Cl)c1=O
Storage condition	2-8℃

Synonyms

1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-one

JNJ-40411813

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