CAS 535-96-6|Marein

Introduction：Basic information about CAS 535-96-6|Marein, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Marein BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Marein
CAS Number	535-96-6	Molecular Weight	450.393
Density	1.7±0.1 g/cm3	Boiling Point	835.4±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₂O₁₁	Melting Point	197-202ºC
MSDS	/	Flash Point	293.5±27.8 °C

Names

Name	marein
Synonym	More Synonyms

Marein BiologicalActivity

Description	Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].
Related Catalog	Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>HDACResearch Areas >>Neurological DiseaseSignaling Pathways >>Epigenetics >>HDAC
Target	IC50: 100 µM (HDAC)[3]
References	[1]. Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. [2]. Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. [3]. B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	835.4±65.0 °C at 760 mmHg
Melting Point	197-202ºC
Molecular Formula	C₂₁H₂₂O₁₁
Molecular Weight	450.393
Flash Point	293.5±27.8 °C
Exact Mass	450.116211
PSA	197.37000
LogP	-0.18
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.751
InChIKey	XGEYXJDOVMEJNG-HTFDPZBKSA-N
SMILES	O=C(C=Cc1ccc(O)c(O)c1)c1ccc(OC2OC(CO)C(O)C(O)C2O)c(O)c1O

Safety Information

Hazard Codes	Xi

Synonyms

4-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-2,3-dihydroxyphenyl β-D-glucopyranoside

β-D-Glucopyranoside de 4-[(2E)-3-(3,4-dihydroxyphényl)-2-propènan-1-oyl]-2,3-dihydroxyphényle

Okanin-4'-O-glucoside

(2E)-3-(3,4-Dihydroxyphenyl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}phenyl)-2-propen-1-one

(E)-3-(3,4-Dihydroxyphenyl)-1-(4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl)-2-propen-1-one

2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-(4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl)-, (E)-

(2E)-3-(3,4-Dihydroxyphényl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}phényl)-2-propén-1-one

4-[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]-2,3-dihydroxyphenyl β-D-glucopyranoside

(2E)-3-(3,4-Dihydroxyphenyl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}phenyl)-2-propen-1-on

2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-, (2E)-

4-[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]-2,3-dihydroxyphenyl b-D-glucopyranoside

Okanin-4'-glucoside

4-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-2,3-dihydroxyphenyl-β-D-glucopyranoside

Marein

2',3,3',4,4'-pentahydroxy-4'-glucosylchalcone

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