CAS 53760-19-3|Cytochalasin H
Introduction：Basic information about CAS 53760-19-3|Cytochalasin H, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cytochalasin H | ||
|---|---|---|---|
| CAS Number | 53760-19-3 | Molecular Weight | 493.63 |
| Density | 1.19g/cm3 | Boiling Point | 676.5ºC at 760mmHg |
| Molecular Formula | C30H39NO5 | Melting Point | 252-258ºC |
| MSDS | ChineseUSA | Flash Point | 362.9ºC |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | cytochalasin h |
|---|---|
| Synonym | More Synonyms |
Cytochalasin H BiologicalActivity
| Description | Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Cytochalasin H (24-72 h) 抑制 A549 细胞的增殖，IC50 值为 159.5 µM[1]。 Cytochalasin H (0-50 µM; 48 h) 在 A549 细胞中诱导细胞凋亡，使细胞周期停滞在 G2/M 期，并影响细胞凋亡相关蛋白的表达[1]。 Cytochalasin H (1-512 μg/mL) 对 MDR 肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性[3]。 Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 µM Incubation Time: 48 h Result: Induced apoptosis in a dose-dependent manner in the A549 cells. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 µM Incubation Time: 48 h Result: Arrested cell cycle at the G2/M phase and sub-G1 peaks. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 µM Incubation Time: 48 h Result: Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3. |
| In Vivo | Cytochalasin H (2.5 mg/kg; i.p.) 可以延迟 Balb/cnu/nu 小鼠中 A549 异种移植肿瘤的生长[2]。 Animal Model: male Balb/cnu/nu mice with A549 xenograft[2] Dosage: 2.5 mg/kg Administration: intraperitoneal injection; 3 injections/week,for 80 days Result: Attenuated tumor growth in vivo. |
| References | [1]. Ma Y, et, al. Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. Oncol Rep. 2018 Jun;39(6):2899-2905. [2]. Yi JM, et, al. In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. Biol Pharm Bull. 2015;38(6):909-12. [3]. Jouda JB, et, al. Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med. 2016 Nov 14;16(1):462. |
Chemical & Physical Properties
| Density | 1.19g/cm3 |
|---|---|
| Boiling Point | 676.5ºC at 760mmHg |
| Melting Point | 252-258ºC |
| Molecular Formula | C30H39NO5 |
| Molecular Weight | 493.63 |
| Flash Point | 362.9ºC |
| Exact Mass | 493.28300 |
| PSA | 95.86000 |
| LogP | 4.06690 |
| Index of Refraction | 1.591 |
| InChIKey | NAEWXXDGBKTIMN-OLSYMYHOSA-N |
| SMILES | C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23C(OC(C)=O)C=CC(C)(O)CC(C)CC=CC3C1O |
| Storage condition | 2-8°C |
| Water Solubility | chloroform: 10 mg/mL, clear, colorless |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2341 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 500 ug/L
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,430,1978
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 500 ug/L
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,430,1978
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330-H361 |
| Precautionary Statements | P260-P264-P280-P284-P302 + P350-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Phrases | 26/27/28-63 |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | HA5306000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
Articles9
More Articles| A new fungal isolate from Paspalum scrobiculatum, Linn. with new biologically active metabolites. Acta Microbiol. Acad. Sci. Hung. 22 , 253, (1975) A new fungal isolate from the host plant Paspalum scrobiculatum Linn., is reported. It is characterized and designated as a separate species Phomopsis paspali (n. sp.), not only for the different morp... | |
| Effects of cytochalasin H on chick embryo explants cultured in vitro. Toxicology 33(3-4) , 323-30, (1984) Effects of the mould metabolite, cytochalasin H (CH) were studied in chick embryos explanted at stages 4, 5 and 8 and cultured in vitro. Morphological and histological observations revealed that the m... | |
| Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter. Exp. Cell Biol. 50(3) , 155-61, (1982) Cytochalasin H (CH) has been shown to inhibit the reaggregation of dissociated cells of a fresh water sponge. The effect is dose-dependent and reversible. Even after 24 h of CH treatment, the cells sh... |
Synonyms
| <11>Cytochalasin |
| paspalin |
| 19-triene-1-one |
| cytochalasin U |
| paspalinpi |
| Paspalin P1 |
| cytochalasinhfromphomopsissp. |
| kodocytochalasin-1 |
