CAS 5957-75-5|(−)-trans-Δ8-tetrahydrocannabinol

Introduction：Basic information about CAS 5957-75-5|(−)-trans-Δ8-tetrahydrocannabinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Articles25
6. Synonyms

Common Name	(−)-trans-Δ8-tetrahydrocannabinol
CAS Number	5957-75-5	Molecular Weight	314.462
Density	1.0±0.1 g/cm3	Boiling Point	383.5±42.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₀O₂	Melting Point	/
MSDS	/	Flash Point	144.5±22.1 °C
Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Names

Name	8-Tetrahydro Cannabinol
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	383.5±42.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₀O₂
Molecular Weight	314.462
Flash Point	144.5±22.1 °C
Exact Mass	314.224579
PSA	29.46000
LogP	7.53
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.529
InChIKey	HCAWPGARWVBULJ-IAGOWNOFSA-N
SMILES	CCCCCc1cc(O)c2c(c1)OC(C)(C)C1CC=C(C)CC21

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP8400000

CHEMICAL NAME :: 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-3-pentyl-6,6,9-trimethyl-, trans(-)-

CAS REGISTRY NUMBER :: 5957-75-5

BEILSTEIN REFERENCE NO. :: 0023921

LAST UPDATED :: 199612

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C21-H30-O2

MOLECULAR WEIGHT :: 314.51

WISWESSER LINE NOTATION :: T B666 HO MU&TTJ CQ E5 I1 I1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - analgesia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 97 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - analgesia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >3150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 59500 mg/kg/17W-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Related to Chronic Data - death

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,703,1977

Safety Information

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F: Flammable;
Risk Phrases	11-39/23/24/25-23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN 1170

Articles25

Effects of cannabinoids in membrane bilayers containing cholesterol.

Biochim. Biophys. Acta 1420(1-2) , 252-65, (1999)

The thermotropic and dynamic properties of the biologically active Delta(8)-tetrahydrocannabinol (Delta(8)-THC) and its inactive congener O-methyl-Delta(8)-tetrahydrocannabinol (Me-Delta(8)-THC) in DP...

Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.

Eur. J. Pharmacol. 563(1-3) , 187-96, (2007)

Xenobiotic cannabinoid CB1/CB2-receptor agonists appear to possess broad-spectrum antiemetic activity since they prevent vomiting produced by a variety of emetic stimuli including the chemotherapeutic...

Loss of THCCOOH from urine specimens stored in polypropylene and polyethylene containers at different temperatures.

J. Anal. Toxicol. 24(7) , 567-71, (2000)

The loss of delta9-tetrahydrocannabinol (THCCOOH) from urine specimens stored in polypropylene and polyethylene containers at 4 degrees C and 25 degrees C was examined. All specimens were analyzed by ...

Synonyms

6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR,10aR)-

D8-THC

δ6-THC

δ8-Tetrahydrocannabinol

δ-8-THC

(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

δ8-THC

(-)-D6-3,4-trans-Tetrahydro-6,6,9-tri methyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol\

6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-

D6-THC

6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-

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