Introduction：Basic information about CAS 1222-57-7|2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine |
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| CAS Number | 1222-57-7 | Molecular Weight | 272.32 |
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| Density | 1.31 g/cm3 | Boiling Point | / |
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| Molecular Formula | C14H12N2O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research[1][2]. |
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| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Others |
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| In Vivo | Zolimidine (200 mg/kg；口服) 降低由 Indomethacin (HY-14397) (5 mg/kg/天，持续 8 天，直肠) 诱导的大鼠肠道溃疡的发生率[2]。Zolimidine (加在饮食中；1% 含量) 可降低豚鼠由角叉菜胶 (加在饮用水中；5% 含量，持续 40 天) 引起的肠溃疡的发生率[2]。 |
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| References | [1]. Belohlavek D, et al. The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing. Scand J Gastroenterol Suppl. 1979;54:44. [2]. Carminati GM, et al. Protective action of zolimidine against two different types of experimental intestinal ulcers. Farmaco, Edizione Pratica (1978), 33(2), 68-79. |
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Chemical & Physical Properties
| Density | 1.31 g/cm3 |
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| Molecular Formula | C14H12N2O2S |
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| Molecular Weight | 272.32 |
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| Exact Mass | 272.06200 |
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| PSA | 59.82000 |
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| LogP | 3.48560 |
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| Index of Refraction | 1.653 |
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| InChIKey | VSLIUWLPFRVCDL-UHFFFAOYSA-N |
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| SMILES | CS(=O)(=O)c1ccc(-c2cn3ccccc3n2)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NJ5758500
- CHEMICAL NAME :
- Imidazo(1,2-a)pyridine, 2-(p-(methylsulfonyl)phenyl)-
- CAS REGISTRY NUMBER :
- 1222-57-7
- BEILSTEIN REFERENCE NO. :
- 0752451
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C14-H12-N2-O2-S
- MOLECULAR WEIGHT :
- 272.34
- WISWESSER LINE NOTATION :
- T56 AN DNJ CR DSW1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3318880
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1655,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 765 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Zolimidine |
| Zolimidin |
| EINECS 214-947-4 |
