CAS 19914-20-6|Enniatin B1
Introduction：Basic information about CAS 19914-20-6|Enniatin B1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Enniatin B1 | ||
|---|---|---|---|
| CAS Number | 19914-20-6 | Molecular Weight | 653.847 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 833.8±65.0 °C at 760 mmHg |
| Molecular Formula | C34H59N3O9 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 458.0±34.3 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Enniatin B1 |
|---|---|
| Synonym | More Synonyms |
Enniatin B1 BiologicalActivity
| Description | Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ACAT ERK NF-κB |
| In Vitro | CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2]. |
| References | [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32. [2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406. [3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 833.8±65.0 °C at 760 mmHg |
| Molecular Formula | C34H59N3O9 |
| Molecular Weight | 653.847 |
| Flash Point | 458.0±34.3 °C |
| Exact Mass | 653.425110 |
| PSA | 139.83000 |
| LogP | 3.58 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.460 |
| InChIKey | UQCSETXJXJTMKO-UMURLBKASA-N |
| SMILES | CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)C)C(=O)OC(C(C)C)C(=O)N1C |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble10mg/mL |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H331 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Hazard Codes | T |
| Risk Phrases | 23/24/25 |
| Safety Phrases | 45 |
| RIDADR | 2811 |
| Packaging Group | I |
Synonyms
| 1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1R)-1-methylpropyl]-, (3S,6R,9S,12R,15R,18R)- |
| 1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1S)-1-methylpropyl]-, (3S,6R,9S,12R,15S,18R)- |
| (3R,6R,9S,12R,15S,18R)-3-[(2R)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| (3S,6R,9S,12R,15S,18R)-3-[(2S)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
