Introduction：Basic information about CAS 533884-09-2|LY500307, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY500307 |
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| CAS Number | 533884-09-2 | Molecular Weight | 282.33 |
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| Density | 1.268 | Boiling Point | 485.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H18O3 | Melting Point | / |
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| MSDS | / | Flash Point | 247.3±28.7 °C |
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Names
| Name | (3aS,4R,9bR)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol |
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| Synonym | More Synonyms |
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LY500307 BiologicalActivity
| Description | Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) inhibitor with Ki and EC50 of 1.54 nM and 3.61 nM, respectively[1]. Anti-tumor activities[2]. |
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| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Neurological Disease |
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| Target | Ki: 1.54 nM (ERβ)[1] EC50: 3.61 nM[1] |
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| In Vitro | Treatment with LY500307 significantly reduces the proliferation of GBM cells with no activity on normal astrocytes in vitro[2]. ERβ agonists promote apoptosis of GBM cells. It modulated several pathways related to apoptosis, cell cycle, and DNA damage response[2]. LY500307 sensitizes GBM cells to several FDA-approved chemotherapeutic drugs including cisplatin, lomustine and temozolomide[2]. |
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| In Vivo | LY500307 treatment significantly reduces tumor growth and promotes apoptosis of GBM tumors in an orthotopic model[2]. LY500307 treatment improves the overall survival of tumor-bearing mice in the GL26 syngeneic glioma model[2]. |
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| References | [1]. Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. [2]. Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185. |
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Chemical & Physical Properties
| Density | 1.268 |
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| Boiling Point | 485.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H18O3 |
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| Molecular Weight | 282.33 |
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| Flash Point | 247.3±28.7 °C |
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| Exact Mass | 282.125580 |
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| PSA | 49.69000 |
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| LogP | 3.84 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.639 |
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| InChIKey | XIESSJVMWNJCGZ-VKJFTORMSA-N |
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| SMILES | Oc1ccc(C2Oc3ccc(O)cc3C3CCCC32)cc1 |
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Synonyms
| Erteberel |
| (3aS,4R,9bR)-4-(4-Hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol |
| Benzo[b]cyclopenta[d]pyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- |
| (3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol |
| LY500307 |
