CAS 19741-14-1|4-Amino-4-deoxy-10-methylpteroic acid
Introduction：Basic information about CAS 19741-14-1|4-Amino-4-deoxy-10-methylpteroic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].
Related Catalog
Signaling Pathways >>Cell Cycle/DNA Damage >>AntifolateResearch Areas >>Inflammation/Immunology
References
[1]. Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.
Chemical & Physical Properties
Density
1.532
Boiling Point
689.3±65.0 °C at 760 mmHg
Melting Point
242 ºC
Molecular Formula
C15H15N7O2
Molecular Weight
325.325
Flash Point
370.7±34.3 °C
Exact Mass
325.128723
PSA
144.14000
LogP
1.75
Vapour Pressure
0.0±2.3 mmHg at 25°C
Index of Refraction
1.799
InChIKey
LWCXZSDKANNOAR-UHFFFAOYSA-N
SMILES
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)O)cc1
Storage condition
2-8°C
Safety Information
Hazard Codes
Xi: Irritant;
Risk Phrases
43-52/53
Safety Phrases
36/37
WGK Germany
3
HS Code
2933990090
Customs
HS Code
2933990090
Summary
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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