Introduction：Basic information about CAS 145572-44-7|Sophocarpine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sophocarpine |
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| CAS Number | 145572-44-7 | Molecular Weight | 246.348 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 425.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H22N2O | Melting Point | / |
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| MSDS | / | Flash Point | 194.0±21.1 °C |
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Names
| Name | 13,14-Didehydromatridin-15-one |
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| Synonym | More Synonyms |
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Sophocarpine BiologicalActivity
| Description | Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>PI3K/Akt/mTOR >>AktResearch Areas >>Inflammation/Immunology |
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| Target | PI3K Akt |
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| References | [1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 425.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H22N2O |
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| Molecular Weight | 246.348 |
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| Flash Point | 194.0±21.1 °C |
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| Exact Mass | 246.173218 |
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| PSA | 23.55000 |
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| LogP | 1.37 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.603 |
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| InChIKey | FBOREIYHDGYUFA-PUILLJIJSA-N |
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| SMILES | O.O=C1C=CCC2C3CCCN4CCCC(CN12)C34 |
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Synonyms
| 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)- |
| Sophocarpine |
| Matridine-13-ene-15-one |
| Matridin-15-one, 13,14-didehydro- |
| Matridin-15-one, 13,14-didehydro- (9CI) |
| 13,14-Didehydromatridin-15-one |
