CAS 15291-75-5|Ginkgolide A

Introduction：Basic information about CAS 15291-75-5|Ginkgolide A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ginkgolide A BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Ginkgolide A
CAS Number	15291-75-5	Molecular Weight	408.399
Density	1.6±0.1 g/cm3	Boiling Point	710.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₄O₉	Melting Point	280°C (dec.)
MSDS	USA	Flash Point	256.5±26.4 °C

Names

Name	Ginkgolide A
Synonym	More Synonyms

Ginkgolide A BiologicalActivity

Description	Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.Target: GABA ReceptorGinkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A significantly shortened the sleeping time induced by anesthetics in mice [1]. Ginkgolide A failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons [2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorNatural Products >>Terpenoids and GlycosidesResearch Areas >>Inflammation/Immunology
References	[1]. Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull, 1993. 16(2): p. 210-2. [2]. Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.

Description

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.Target: GABA ReceptorGinkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A significantly shortened the sleeping time induced by anesthetics in mice [1]. Ginkgolide A failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons [2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorNatural Products >>Terpenoids and GlycosidesResearch Areas >>Inflammation/Immunology

References

[1]. Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull, 1993. 16(2): p. 210-2.

[2]. Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	710.1±60.0 °C at 760 mmHg
Melting Point	280°C (dec.)
Molecular Formula	C₂₀H₂₄O₉
Molecular Weight	408.399
Flash Point	256.5±26.4 °C
Exact Mass	408.142029
PSA	128.59000
LogP	-0.13
Vapour Pressure	0.0±5.1 mmHg at 25°C
Index of Refraction	1.631
InChIKey	FPUXKXIZEIDQKW-CBRQLGEBSA-N
SMILES	CC1C(=O)OC2CC34C5CC(C(C)(C)C)C36C(OC(=O)C6O)OC4(C(=O)O5)C21O
Storage condition	2-8°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
RIDADR	NONH for all modes of transport
WGK Germany	3

Synonyms

Ginkgolid A

(1R,3R,7S,8S,10R,11S,13S,16S,17R)-8-tert-Butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione

6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b-dihydroxy-5-methyl-, (3aR,4aR,4bR,5S,7aS,8aS,9R,11S,11aS)-

BN 5202

GINKGOLIDE A,GINKGO BILOBA L

PRIMULIC ACID 1

gingkolide A

ginkolide A

GINKGOBILOBAP.E.

1,7-DIDEOXYGINKGOLIDE C

ginkgolide a from ginkgo biloba leaves

MFCD07437829

GINKGOLIDE A FROM GINKGO LEAVES

GinkgolideA

(1R,3R,7S,8S,10R,11S,13S,16S,17R)-6,17-Dihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione

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